沈亚领
 

   生物工程专业：博士生导师/硕士生导师
         生物化工专业：博士生导师
         生物工程领域：工程硕士导师

  沈亚领，男，工学博士，生物反应器工程国家重点实验室和4688美高梅集团唯一教授，长期从事生物工程科学领域的研究工作。承担和完成国家级、省部级及横向课题项目20多项；与企业合作研发获临床批件5件；在相关学科领域发表论文100多篇，其中Sci论文58篇，获授权发明专利16项；获省部级奖3次，出版译著两部，参编著作四部；指导的研究生学位论文三次获得上海市研究生优秀成果奖。

主要研究方向：
1． 生物工程/生物化工/微生物学：生物基化学品；代谢工程和合成生物学；发酵生理。

2．生物医药：蛋白质/多肽药物、小分子药物产业化研发；靶向递药系统；生物下游过程

联系方式：

实验十四楼东楼（鲁华所）301室

电话: 021-64253156

Email: ylshen@ecust.edu.cn

近年主要论文：

1.Feirong Gong, Dan Chen, Xin Teng, Junhua Ge, Xianfeng Ning, Ya-ling Shenet al, Curcumin-Loaded Blood-Stable Polymeric Micelles for Enhancing Therapeutic Effect on Erythroleukemia, Molecular Pharmaceutics, 2017, 14, 2585−2594

2.Xianghai Cai, Wei Wang, Lin Lin, Dannong He, Gang Huang, Yaling  Shenet al，Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards  pyrethroid  pesticides，Scientific Reports，2017 | 7: 3461

3.Yali Guo, Lu Dai, Bo Xin, Fei Tao, Hongzhi Tang, Yaling Shen, Ping Xu,  1,3-Propanediol production by a newly isolated strain, Clostridium perfringens GYL, Bioresource Technology, 2017, 233, 406–412

4.Xianghai Cai, Wei Wang, Lin Lin, Dannong He, Yaling Shen* et al, Cinnamyl Esters Synthesis By Lipase-Catalyzed Transesterification in a Non-Aqueous System, Catalysis Letters, 2017, 147(4):946–952

5.Xin Lv, Lu Dai, Fangmin Bai, Zhanqing Wang, Liaoyuan Zhang and Yaling Shen*, Metabolic engineering of Serratia marcescens MG1 for enhanced production of (3R)‑acetoin Bioresour. Bioprocess.  2016, 3(1): 52.

6.Xianghai Cai, Siqi Chen, Hong Yang, Wei Wang, Lin Lin, Yaling Shen et al,  Biodegradation of waste greases and biochemical properties of a novel lipase from Pseudomonas synxantha PS1, Can. J. Microbiol.2016, 62: 588–599

7.Xinxin Lv, Jian Zhang, Rui Xu, Yuguo Dong, Aiyou Sun*, Yaling Shen, Dongzhi Wei. Gigantoxin-4-4D5 scFv is a novel recombinant immunotoxin with specific toxicity against HER2/neu-positive ovarian carcinoma cells. Applied Microbiology and Biotechnology,  2016, 100, 6403–6413

8.Xiaoxiong Han, Dan Chen, Jing Sun, Jinsong Zhou, Duan Li, Feirong Gong, Yaling Shen*，A novel cabazitaxel-loaded polymeric micelle system with superior in vitro stability and long blood circulation time, Journal of Biomaterials Science, Polymer Edition, 2016, 27(7), 626-642

9.Rao Ben , Fan Jiying , Sun Jian’an , Truong Ngoc Tu, Sun Jing, Zhou Jingsong, Qiuyi, Shen Yaling*, An auto-inducing expression system based on RhlI-RhlR Quorum sensing regulon for recombinant protein production in E.coli, Biotechnology and Bioprocess Engineering,2016, 21(1), 160-168

10.Jiying Fan, Zhanqing Wang, Liying Huang, Yaling Shen*, Efficient refolding of the bifunctional therapeutic fusion protein VAS-TRAIL by a triple agent solution, Protein Expression and Purification , 2016, 125 , 68-73

11.Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan & Yaling Shen*, Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241, Scientific Reports， 6, 19257; doi: 10.1038/srep19257 (2016)

12.Jiying Fan, Liying Huang, Jing Sun, Yi Qiu, Jinsong Zhou, Yaling Shen*, Strategy for linker selection to enhance refolding and bioactivity of VAS-TRAIL fusion protein based on inclusion body conformation and activity, Journal of Biotechnology, 2015, 209 , 16–22

13.Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao,  Liaoyuan Zhang, Yaling Shen*, Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)- 2,3-butanediol production, Journal of Industrial Microbiology and Biotechnology, 2015, 42(6), 779-786

14.Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*, Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin, Journal of Chemical Technology and Biotechnology, 2015，90，93–100

15.Liaoyuan Zhang, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yulong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology， 2014，41(9)，1319–1327

16.Liaoyuan Zhang*, Quanming Xu, Senran Zhan, Hui Lin, Shujing Sun, Li Sha,Xiong Guan, Kaihui Hu, Yaling Shen*，A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30，Applied Microbiology and Biotechnology，2014，98， 1175-1184

17.Jian-An Sun, Liao-Yuan Zhang, Ben Rao, Ya-Ling Shen* et al, Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase，Bioresource Technology，2012，119，94-98

18.Ben Rao，Liao Yuan Zhang，Jian’an Sun，Yaling Shen* et al，Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens，Applied Microbiology and Biotechnology，2012，93（5），2147-2159

主要专著：
 1． Steven L Nail（美国）等著，童望宇，沈亚领，张勰旻等译，《蛋白质药物-开发与生产》，北京，化学工业出版社，2006
 2． 余儒均，李爽，沈亚领：氨基酸，《生物化学品》（王家勤主编），1-45，北京，中国物质出版社，2001
 3． Moser. A 著，曲音波，沈亚领等译：《生物工艺技术学——动力学及反应器》（Springer Verlag New York Inc.授权湖南科学技术出版社，1994）

联系方式：

实验十四楼东楼（鲁华所）301室

电话: 021-64253156

Email: ylshen@ecust.edu.cn